Effect of Octreotide Treatment on Graves' Ophthalmopathy.

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Effect of octreotide treatment on Graves' ophthalmopathy.

In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months. The mean age was 49+/-13 years. All patients were under either propylthiouracil or methimazole therapy and were euthyroid for at le...

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Octreotide-scintigraphy is a disease-activity parameter in Graves' ophthalmopathy.

OBJECTIVE It is thought that immunosuppressive treatment of Graves' ophthalmopathy should be restricted to patients with active eye disease, but assessing disease activity is difficult. Octreotide scintigraphy has been claimed to differentiate active from inactive disease. Here we study the intraobserver variability and diagnostic accuracy of the quantitative measurement of orbital octreotide u...

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The pathogenesis and treatment of Graves' ophthalmopathy.

Graves' ophthalmopathy (GO) is probably an autoimmune condition although the pathogenesis is still not fully understood. GO is frequently, though not invariably, associated with Graves' disease and it may in fact be a separate disease entity. Ophthalmopathy is commonest in the 30 to 50 age group",2'3 and is more common in women (2:1, female:male), although the female preponderance is not so mar...

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Graves’ Ophthalmopathy

Copyright © 2009 Massachusetts Medical Society. A 40-year-old woman who recently received a diagnosis of Graves’ disease comes for a follow-up visit. She has been taking methimazole, at a dose of 10 mg daily, and is now euthyroid, but for the past 3 months, she has had bothersome eye symptoms, including redness, tearing, grittiness, photophobia, diplopia at the extremes of gaze, and ocular pain...

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Update on the medical treatment of Graves’ ophthalmopathy

PURPOSE To review recent advances in the understanding of Graves' ophthalmopathy (GO) pathogenesis as well as discuss current and future medical management strategies. DESIGN Interpretive essay. METHODS Literature review and interpretation. RESULTS Medical treatment of GO has slowly evolved during the past few decades and has been hampered by a poor understanding of the disease at a cellu...

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ژورنال

عنوان ژورنال: Endocrine Journal

سال: 1999

ISSN: 0918-8959,1348-4540

DOI: 10.1507/endocrj.46.573